Repository Universitas Ahmad Dahlan

Anti-inflammatory Activity of Ointment in Water Soluble Base of Volatile Oil of Syzygium aromaticum with Variation Composition of Oleic acid and Propylene glycol as Enhancer

Downloads

Downloads per month over past year

Rahmawati, Dewi and Sugihartini, Nining and Yuwono, Tedjo (2017) Anti-inflammatory Activity of Ointment in Water Soluble Base of Volatile Oil of Syzygium aromaticum with Variation Composition of Oleic acid and Propylene glycol as Enhancer. UNSPECIFIED.

[img] Text
17.Anti_inflammatory_Activity_of_Ointment_in_Water_So-9-11.pdf

Download (20kB)

Abstract

ABSTRACT Background: The dosage form of ointment clove essential oil in water-soluble base has proven efficacious as antiinflammatory with eugenol as active substance. Further research to increase the penetration of eugenol in penetrating the skin layer needs to be done with the addition of enhancer. Purpose: To determine the anti-inflammatory activity of ointment base water soluble of clove essential oil with composition variation of oleic acid and propylene glycol as enhancers. Methods: The ointment was made using fusion method. Addition of enhancer composition refers to the system Simplex Lattice Design for Formula 1, Formula 2 and Formula 3 successively used: 100% oleic acid; 50% oleic acid: 50% propylene glycol; and 100% propylene glycol. The evaluation of anti-inflammatory activity was based on the parameters epidermal thickness, the number of inflammatory cells, and the number of cells that expressed cyclooxygenase-2 (COX-2). The antiinflammatory tests used male mice strain BALB/C which was induced by croton oil. Results: The enhancer composition of oleic acid and propylene glycol affect the activity of ointment clove essential oil in water-soluble base. Conclusion: The increasing composition of propylene glycol improved anti-inflammatory activity of ointment. Key words: essential oil of clove, water-soluble ointment base, anti-inflammatory, enhancer.

Item Type: Other
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy (Fakultas Farmasi) > S2-Master of Pharmacy (S2-Farmasi)
Depositing User: nining sugihartini
Date Deposited: 07 Mar 2018 04:33
Last Modified: 07 Mar 2018 04:33
URI: http://eprints.uad.ac.id/id/eprint/8982

Actions (login required)

View Item View Item

Repository Universitas Ahmad Dahlan is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.