Physical characteristic and irritation index of Syzigium aromaticum essential oil in O/W and W/O creams

Safriani, R and Sugihartini, Nining and Yuliani, S (2017) Physical characteristic and irritation index of Syzigium aromaticum essential oil in O/W and W/O creams. Fakultas Farmasi, Universitas Ahmad Dahlan.

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Abstract

Abstract. Essential oil of Syzigium aromaticum has been formulated in O/W and W/O creams
as anti-inflammatory dosage form. The purpose of this study was to evaluate the physical
characteristic and irritation index of S. aromaticum essential oil in O/W and W/O creams. The
creams were made by fusion method. The creams then were evaluated the physical
characteristic including pH, viscosity, spreadability and adhesivity. The irritation index was
obtained by irritation skin test in male rabbit. The results showed that the W/O and O/W
creams have the value of pH: 6.3 and 6.27; spreadability: 3,18 and 4.17 cm2; adhesivity: 5.59
and 0.07 minutes; viscosity: 4.43 and 2.88 Pa.S, respectively. The irritation test showed that
the control enhancer caused mild irritation in both of W/O and O/W creams. These findings
indicated that type of cream might influence the physical characteristic and irritation index of
S. aromaticum essential oil cream.
Keywords: S. aromaticum, essential oil, physical characteristic, irritation index, cream

Item Type:	Other
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S2-Master of Pharmacy (S2-Farmasi)
Depositing User:	Nining Sugihartini
Date Deposited:	07 Mar 2018 03:57
Last Modified:	07 Mar 2018 03:57
URI:	http://eprints.uad.ac.id/id/eprint/9017

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