The Antioxidant Effect of Bangle (Zingiber cassumunar) Rhizome Extract on Superoxide Dismutase (sod) Activity in Hyperlipidemic Rats

Sari, Novita and Nurkhasanah, Nurkhasanah and Sulistyani, Nanik (2020) The Antioxidant Effect of Bangle (Zingiber cassumunar) Rhizome Extract on Superoxide Dismutase (sod) Activity in Hyperlipidemic Rats. [Artikel Dosen]

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Abstract

High-fat diet can cause increase in formation of reactive oxygen species (ROS). Bangle (Zingiber Cassumunar) rhizome is potential an antioxidant and can restore oxidative balance. The purpose of this study was to evaluate the effects of extract Z. cassumunar rhizome on superoxide dismutase (SOD) enzyme activity in rat induced by high-fat diet (HFD). Twenty-five rats were divided randomly into five groups; group I: normal control (standard-fed); groups II: hyperlipidemia (HFD+propylthiouracil (PTU) 0.05%); group III, IV and V: administered HFD+PTU 0.05% and different dose of Z. cassumunar rhizome extracts ( 100, 200 and 400 mg/kg BB). The rats were fed with HFD+PTU 0.05% for 14 days and extract of Z. cassumunar treatment for 28 days simultaneously. Rats were fasted overnight and euthanized by neck dislocation. Liver was separated for measurement of SOD activity. The statistical analysis that had been done used ANOVA with an LSD test. The intake of Rhizome Z. Cassumunar extract 400 mg/kg BW per day in rats induced HFD, significantly increased SOD activity compared to the control group and HFD group (P<0.05). Z. Cassumunar Rhizome has been shown to effectively increase antioxidant activity and minimize the adverse effects of HFD.

Item Type: Artikel Dosen
Subjects: Q Science > Q Science (General)
Q Science > QR Microbiology
R Medicine > R Medicine (General)
R Medicine > RS Pharmacy and materia medica
Divisi / Prodi: Faculty of Pharmacy (Fakultas Farmasi) > Program of Professional Pharmacist
Depositing User: Dr Nanik Sulistyani
Date Deposited: 16 Jan 2021 22:19
Last Modified: 16 Jan 2021 22:19
URI: http://eprints.uad.ac.id/id/eprint/21994

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