Hasil cek similarity" Identification of SNP rs1799853 of CYP2C9 Gene and Blood Sugar Levels in Diabetic Patients"

Perwitasari, Dyah Aryani and Faridah, Imaniar Noor and Maliza, Rita and Dania, Haafizah and Irham, Lalu Muhammad (2021) Hasil cek similarity" Identification of SNP rs1799853 of CYP2C9 Gene and Blood Sugar Levels in Diabetic Patients". Asian Journal of Pharmacology & Toxicology.

Text HASIL CEK_Identification of SNP rs1799853 of CYP2C9 Gene and Blood Sugar Levels In Diabetic Patients (1).pdf Download (1MB)

Abstract

Introduction: The high prevalence of Diabetes Mellitus Type 2 (DMT2) became the burden in Indonesia. Some factors may influence the antidiabetic response including genetics, physiology, pathophysiology and the environment. Around 15–30% of genetic variation results to the differences of metabolism and drug response between individuals. The purpose of this study is to identify the genotype of CYP2C9 gene in rs1799853 and the therapeutic outcome of blood sugar levels in T2DM patients. Methods: We conducted a cross-sectional-prospective research at Moewardi Hospital Surakarta. We collected the blood sample of 10 T2DM patients who received Sulphonylurea monotherapy. The fasting blood sugar (FBS), 2-hour postprandial blood sugar and HbA1c were measured as therapeutic outcomes. Result: We found the dominant result is the wild type (CC) with 90.9% and mutant heterozygous (CT) were 9.1%. Subjects with wild type show the uncontroll of Fasting blood glucose and HbA1C. Conclusion: The SNP mutation of CYP2C9 rs1799853 gene found in T2DM patients at Moewardi Hospital Surakarta, Solo who received sulphonylurea therapy.

Item Type:	Artikel Umum
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S2-Master of Pharmacy (S2-Farmasi)
Depositing User:	Lalu Muhammad Irham, M.Farm., Ph.D
Date Deposited:	09 Jun 2022 01:43
Last Modified:	02 Nov 2022 06:40
URI:	http://eprints.uad.ac.id/id/eprint/35191

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