Hasil cek similarity" Comparative Effect of Yellow Root (Arcangelisia Flava (L) Merr) Water and Brackish Water Decoction on Biochemical Profiles of Renal Function and Histopathological Profiles of Renal and Uterus in Wistar Female Rats"

Pramono, Suwijiyo and Paramidhita, Risqika Y.T and Marini, Marini and Bachri, Moch. Saiful (2020) Hasil cek similarity" Comparative Effect of Yellow Root (Arcangelisia Flava (L) Merr) Water and Brackish Water Decoction on Biochemical Profiles of Renal Function and Histopathological Profiles of Renal and Uterus in Wistar Female Rats". Majalah Obat Tradisional, 25 (2). ISSN 2406-9086 (Submitted)

Text (HASIL CEK SIMILARITY) HASIL CEK_Bachri_Arcangelisia flava_ subchronic renal and uterus toxicity_ berberine (1).pdf - Published Version Download (2MB)

Abstract

Yellow root (Arcangelisia flava (L.) Merr.) is a medicinal plant used traditionally in Borneo, Indonesia, for several diseases. Nevertheless, it contains berberine alkaloids that are considered harmful. Empirically, based on local wisdom people do not boil yellow roots with water but with brackish water. This study aimed to determine the effects of yellow root decoctions made using water and brackish water on blood biochemical and histopathological profile of kidneys and uterus in Wistar rats after subchronic treatment. Overall, 70 Wistar female rats were divided into seven groups of which three groups were given yellow root water decoctions and three groups were given yellow root brackish water decoctions with doses equivalent to 1.25 g/kg BW, 2.5 g/kg BW and 5 g/kg BW of dried yellow root, whereas the control group was only given Aquadest. After 28 days of treatments, blood samples were obtained for biochemical examination followed by a surgical examination to observe the histological features of the organs. The results revealed significant differences in the blood urea nitrogen (BUN) levels between group that was given water decoction of the yellow root and the control group. On the other hand, the groups that were given brackish water decoction revealed no significant changes, except at the highest dose. Furthermore, histopathological features of rats treated using all doses of the yellow root water decoctions revealed organ damage compared with the normal group, manifested as hemorrhage, degeneration, and necrosis of the kidneys, as well as epithelial damage and inflammatory infiltration of the uterus.

Item Type:	Artikel Umum
Keyword:	Arcangelisia flava; Subchronic renal and uterus toxicity; Berberine
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > Program of Professional Pharmacist
Depositing User:	Moch. Saiful Bachri
Date Deposited:	22 Nov 2022 06:43
Last Modified:	22 Nov 2022 06:43
URI:	http://eprints.uad.ac.id/id/eprint/37568

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