Alpha-Glucosidase Inhibitory Assay-Screened Isolation and Molecular Docking Model from Bauhinia pulla Active Compounds

Dej-adisai, Sukanya and Rais, Ichwan Ridwan and Wattanapiromsakul, Chatchai and Pitakbut, Thanet (2021) Alpha-Glucosidase Inhibitory Assay-Screened Isolation and Molecular Docking Model from Bauhinia pulla Active Compounds. Molecules, 26.

	Text 12%_HASIL CEK_Rais_Bauhinia pulla_ anti-diabetic_ alpha-glucosidase inhibition_ molecular docking.pdf Download (3MB)
	Text Molecules_Bukti submit.pdf Download (409kB)
	Text Hasil review_Alpha.pdf Download (1MB)

Abstract

The aim of this research was to establish the constituents of Bauhinia pulla as anti-diabetic
agents. A phytochemistry analysis was conducted by chromatographic and spectroscopic techniques.
The alpha-glucosidase inhibitory assay screening resulted in the isolation of eight known compounds
of quercetin, quercitrin, luteolin, 5-deoxyluteolin, 4-methyl ether isoliquiritigenin, 3,20,40-trihydroxy-
4-methoxychalcone, stigmasterol and �-sitosterol. Ethanol leaf extracts showed potential effects,
which led to a strong inhibitory activity of isolated quercetin at 138.95 �g/mL and 5.41 �g/mL of
IC50, respectively. The docking confirmed that flavonoids and chalcones had the same potential
binding sites and responsibilities for their activity. This study was the first report of Bauhinia pulla
chemical constituents and its alpha-glucosidase inhibition.

Item Type:	Artikel Umum
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi)
Depositing User:	Ichwan Ridwan Rais
Date Deposited:	02 Mar 2023 09:44
Last Modified:	25 Mar 2023 03:11
URI:	http://eprints.uad.ac.id/id/eprint/40317

Actions (login required)

View Item