Dej-adisai, Sukanya and Rais, Ichwan Ridwan and Wattanapiromsakul, Chatchai and Pitakbut, Thanet (2021) Alpha-Glucosidase Inhibitory Assay-Screened Isolation and Molecular Docking Model from Bauhinia pulla Active Compounds. Molecules, 26.
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12%_HASIL CEK_Rais_Bauhinia pulla_ anti-diabetic_ alpha-glucosidase inhibition_ molecular docking.pdf Download (3MB) |
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Abstract
The aim of this research was to establish the constituents of Bauhinia pulla as anti-diabetic
agents. A phytochemistry analysis was conducted by chromatographic and spectroscopic techniques.
The alpha-glucosidase inhibitory assay screening resulted in the isolation of eight known compounds
of quercetin, quercitrin, luteolin, 5-deoxyluteolin, 4-methyl ether isoliquiritigenin, 3,20,40-trihydroxy-
4-methoxychalcone, stigmasterol and �-sitosterol. Ethanol leaf extracts showed potential effects,
which led to a strong inhibitory activity of isolated quercetin at 138.95 �g/mL and 5.41 �g/mL of
IC50, respectively. The docking confirmed that flavonoids and chalcones had the same potential
binding sites and responsibilities for their activity. This study was the first report of Bauhinia pulla
chemical constituents and its alpha-glucosidase inhibition.
Item Type: | Artikel Umum |
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Subjects: | R Medicine > RS Pharmacy and materia medica |
Divisi / Prodi: | Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi) |
Depositing User: | Ichwan Ridwan Rais |
Date Deposited: | 02 Mar 2023 09:44 |
Last Modified: | 25 Mar 2023 03:11 |
URI: | http://eprints.uad.ac.id/id/eprint/40317 |
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