Antibacterial activity of essential oils from Eucalyptus and of selected components against multidrug-resistant bacterial pathogens

Mulyaningsih, Sri and Sporer, Frank and Reichling, Juergen and Wink, Michael (2011) Antibacterial activity of essential oils from Eucalyptus and of selected components against multidrug-resistant bacterial pathogens. Pharmaceutical Biology, 49 (9). pp. 893-899. ISSN ISSN 1388-0209 print/ISSN 1744-5116 online

Text HASIL CEK_Mulyaningsih_Eucalyptus, essential oil, antimicrobial activity, aromadendrene, 1,8-cineole, multidrug-resistant bacteria (1).pdf Download (2MB)

Abstract

Context: Eucalyptus globulus Labill (Myrtaceae) is the principal source of eucalyptus oil in the world and has been used as an antiseptic and for relieving symptoms of cough, cold, sore throat, and other infections. The oil, well known as ‘eucalyptus oil’ commercially, has been produced from the leaves. Biological properties of the essential oil of fruits
from E. globulus have not been investigated much.
Objective: The present study was performed to examine the antimicrobial activity of the fruit oil of E. globulus (EGF)
and the leaf oils of E. globulus (EGL), E. radiata Sieber ex DC (ERL) and E. citriodora Hook (ECL) against multidrugresistant
(MDR) bacteria. Furthermore, this study was attempted to characterize the oils as well as to establish a
relationship between the chemical composition and the corresponding antimicrobial properties.
Materials and methods: The chemical composition of the oils was analyzed by GLC-MS. The oils and isolated major
components of the oils were tested against MDR bacteria using the broth microdilution method.
Results: EGF exerted the most pronounced activity against methicillin-resistant Staphylococcus aureus (MIC ~ 250 μg/ml).
EGF mainly consisted of aromadendrene (31.17%), whereas ECL had citronellal (90.07%) and citronellol (4.32%) as the
major compounds. 1,8-cineole was most abundant in EGL (86.51%) and ERL (82.66%).
Discussion and conclusion: The activity of the oils can be ranked as EGF > ECL > ERL ~ EGL. However, all the oils and
the components were hardly active against MDR Gram-negative bacteria. Aromadendrene was found to be the most
active, followed by citronellol, citronellal and 1,8-cineole.

Item Type:	Artikel Umum
Keyword:	Eucalyptus, essential oil, antimicrobial activity, aromadendrene, 1,8-cineole, multidrug-resistant bacteria
Subjects:	Q Science > QR Microbiology R Medicine > RS Pharmacy and materia medica
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi)
Depositing User:	Sri Mulyaningsih
Date Deposited:	11 Aug 2023 03:17
Last Modified:	11 Aug 2023 03:17
URI:	http://eprints.uad.ac.id/id/eprint/44074

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