The effect of polyvinylpyrrolidone (PVP) to the in vitro intensia absorption of pentagamavunon absorption of pentagamavunon- 0(PGV)on rats

Wahyuningsih, Iis and Yuwono, Tedjo and Oetari, Oetari (2009) The effect of polyvinylpyrrolidone (PVP) to the in vitro intensia absorption of pentagamavunon absorption of pentagamavunon- 0(PGV)on rats. 5. Proseding the first international seminar on science and technology. pp. 851-854. ISSN 978-979-19201-0-0

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Abstract

PGV-0 is a synthetic compound which is modified compound from curcumin. This compound whould be expected to be a new drug, since this substance has a potent inflammatory effect with a very low toxicity. However, this substance has poor biopharmaceutic properties, it means that this compound is practically incoluble in water. It has been reported, that the solubility of PGV-0 was increasd by presence of PVP. So the aims of this study was to know the effect of PVP to the in vitro intestinal absorption of PGV-0 on rats. It wasevident that the PGV-0absorption was increased significantly by PVP addition, but there was not any effect on the lag time of the in vitro intestinal absorption.
Key words: PVV-0, PVP, in vitro absorption

Item Type:	Artikel Umum
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi)
Depositing User:	Iis Wahyuningsih
Date Deposited:	13 Apr 2019 02:22
Last Modified:	13 Apr 2019 02:22
URI:	http://eprints.uad.ac.id/id/eprint/13644

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