Wakidah, Nurul (2019) AKTIVITAS SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) PIROKSIKAM TERHADAP EKSPRESI TNF-α PADA LAMBUNG TIKUS BETINA GALUR WISTAR Activity of Self-Nanoemulsifying Drug Delivery System (SNEDDS) of Piroxicam on TNF-α Expression in Gastric of Wistar Rats. Bachelor thesis, Universitas Ahmad Dahlan.
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Abstract
Piroxicam is an acidic drug and many of them are deposited in the stomach which can cause
erosion. Erosion of the gastric or submucosal mucosa is an event that must be inhibited. One parameter in the inflammatory event is the tnf-α expression. The purpose of this study was to determine the effect of the formation of SNEDDS pyroxicam on anti-inflammatory activity in TNFα expression.
This study used 30 female white wistar rats with a weight of 100-150 grams. Rats were divided into 6 groups. Group 1 was aquadest control group, group II was base, group III was SNEDDS Piroxicam group, group IV was 1% PVP group, group V was oleic acid group, and group VI was the pyroxicam suspension group. Rats were treated, then waited for 5 hours, after which rats were sacrificed and gastric organs were taken for immunohistochemical testing of TNF-α expression.
The data obtained were percent of TNF-α expression analyzed using one way ANOVA test with 95% confidence level.
Immunohistochemical test results showed the TNF-α expression of the SNEDDS group was significantly different from the piroxicam suspension. The percentage inhibition of TNF-α expression from pyroxycam SNEDDS was 54.14%.
Based on the research it can be concluded that the preparation of Pyroxycam Self Nanoemulsifying Drug Delivery System (SNEDDS) can reduce TNF-α expression compared to the piroxicam suspension group. Percent inhibition of TNF-α expression from pyroxycam SNEDDS was
54.14%.
Keywords: Piroxicam, SNEDDS, Peptic Ulcer, Immunohistochemistry, TNF-α Expression
| Item Type: | Thesis (Bachelor) |
|---|---|
| Subjects: | R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisi / Prodi: | Faculty of Public Health (Fakultas Kesehatan Masyarakat) > S1-Science in Public Health (S1-Kesehatan Masyarakat) |
| Depositing User: | publikasi uad |
| Date Deposited: | 01 Oct 2019 01:31 |
| Last Modified: | 01 Oct 2019 01:31 |
| URI: | http://eprints.uad.ac.id/id/eprint/15058 |
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