EFFECT OF ASPIRIN RESISTANCE WITH DYSLIPIDEMIA AGAINST VERIFYNOW® MEASUREMENT IN BETHESDA HOSPITAL YOGYAKARTA.

Witasari, Hardi Astuti and Rizaldy Taslim, Pinzon and Erna, Kristin (2015) EFFECT OF ASPIRIN RESISTANCE WITH DYSLIPIDEMIA AGAINST VERIFYNOW® MEASUREMENT IN BETHESDA HOSPITAL YOGYAKARTA. EFFECT OF ASPIRIN RESISTANCE WITH DYSLIPIDEMIA AGAINST VERIFYNOW® MEASUREMENT IN BETHESDA HOSPITAL YOGYAKARTA., 7 (2). pp. 41-45. ISSN ISSN 2085-4145 (Print), ISSN 2527-2950 (Online)

Text EFFECT OF ASPIRIN RESISTANCE WITH DYSLIPIDEMIA AGAINST VERIFYNOW® MEASUREMENT IN BETHESDA HOSPITAL YOGYAKARTA.pdf Download (232kB)

Abstract

Background: Aspirin is first line drug of choice to prevent ischemic
stroke. However, some cases are found occuring of aspirin resistance.
Objective: This study was to examine the effect of dyslipidemia on the
risk of antiplatelet resistance with VerifyNOW® at Bethesda Hospital
Yogyakarta.
Method: This research was observational analysis using a nested case�control study design. The subjects were ischemic stroke patients who
underwent tests of platelet function by VerifyNOW® (Accumetrics, San
Diego, CA, USA). The Case group was ischemic stroke patients who has
history of aspirin resistance. The control group was ischemic stroke
patients who response on aspirin therapy. Both groups were analyzed and
compared to the state of dyslipidemia.
Results: Bivariate analysis on the incidence of aspirin resistance indicate
that dyslipidemia had OR = 0.979 (95% CI; 0.378 to 2.531), p = 0.572.
Hypercholesterolemia had OR = 0,909 (CI 95%; 0,377-2,190) p = 0,500;
hypertrigliceride had OR = 0,838 (CI 95%; 0,331-2,119) p = 0,409;
abnormal HDL had OR = 1,468 (CI 95% 0,564-3,817) p = 0,238; abnormal
LDL had OR = 0,937 (CI 95% 0,374-2,345) p = 0,500. Patient factors such
as age >55 years (p = 0.168) and female gender (p = 0.226) showed a non�significant results.
Conclusion: Ischemic stroke patients at Bethesda Hospital Yogyakarta
who had dyslipidemia were not evident to have a greater risk of
aspirin resistance than ischemic stroke patients who did not undergo
dyslipidemia

Item Type:	Artikel Umum
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi)
Depositing User:	M.Sc,.Apt Hardi Astuti Witasari
Date Deposited:	11 Jan 2022 02:41
Last Modified:	11 Jan 2022 02:41
URI:	http://eprints.uad.ac.id/id/eprint/31352

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