Peer Review Subchronic Toxicity of Green Algae (Spyrogyra sp.) Ethanolic Extract on Hematologic Parameters

Salamah, Nina and Widyaningsih, Wahyu and Susanti, Hari and Devi, Anggita and Sejati, Anita Wening and Putri, Zahra Alya (2016) Peer Review Subchronic Toxicity of Green Algae (Spyrogyra sp.) Ethanolic Extract on Hematologic Parameters. [Artikel Dosen]

Text (PEER REVIEW) Peer Review - Susanti - green algae hematologic homeostasis spyrogyra sp subcronic toxicity.pdf Download (1MB)

Abstract

Green Algae, an organism with active substance such as phytomelatonin, has
potential to be developed as Indonesian traditional medicine. As the long
term addition of Green Algae ethanol extract (Ekstrak etanol ganggang
hijau, EEGH) influences the hematology system, in this paper, the safety test
was done to ensure the safety of its use through subchronic toxicity test of
EEGH on the hematology parameters of Wistar rats. The test group consisted
of three groups treated with EEGH 100 mg/kg, 200 mg/kg, and 400 mg/kg,
while the control group was given by 0.5% CMC-Na, with 8 rats each
respectively. By using blood samples taken from orbital sinus on the 29th
day, common hematologic parameters (erythrocytes, leukocytes, and
hemoglobin level), the parameters of hemostasis (platelets, pT, aPTT, BT)
and immune parameters (Differential Leukocytes Counts include neutrophils
segment, lymphocytes, monocytes, and eosinophils) were finally observed
and showed that the 28 days-addition of EEGH increase the hematological
parameters of Wistar rats

Item Type:	Artikel Dosen
Subjects:	Q Science > Q Science (General) R Medicine > R Medicine (General) T Technology > T Technology (General)
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > Pharmacy Doc
Depositing User:	Mrs Hari Susanti
Date Deposited:	21 May 2022 01:15
Last Modified:	21 May 2022 01:15
URI:	http://eprints.uad.ac.id/id/eprint/32311

Actions (login required)

View Item