Hasil cek similarity" Plasma Jet–Treated Lidah Buaya (Aloe Vera) Influences Proliferative-Phase Wound Healing"

Nurani, Laela Hayu and Nasruddin, Nasruddin and Damarwati, Sri and Wahyuningtyas, Eka Sakti and Safitri, E.I. and Junita, E. and Ningrum, Y.D.A. and Rahmawati, R.P. and Astuti, R.A. and Sikumbang, I.M. and Kartikadewi, A. and Sari, Y and Mukaromah, A.H. and Anita, D.C. and Ishijima, Tatsuo and Nakatani, Toshio (2020) Hasil cek similarity" Plasma Jet–Treated Lidah Buaya (Aloe Vera) Influences Proliferative-Phase Wound Healing". Begell House Inc., Plasma Medicine.

Text HASIL CEK_Plasma Jet–Treated Lidah Buaya (Aloe Vera) Influences Proliferative-Phase Wound Healing.pdf Download (4MB)

Abstract

An in vivo experimental study was conducted to evaluate the effect of a plasma-treated aloe vera slice on cutaneous acute wound healing using a small animal model. A nonequilibrium atmospheric plasma pressure jet (N-APPJ) was developed. Aloe vera slices with thicknesses of approximately 2 mm were treated by N-APPJ at distances of 5 mm, 10 mm, and 20 mm before application. Possible reactive species on the surfaces of the plasma-treated aloe vera slices were chemically identified. Forty-five male Balb/c mice, aged 7−8 weeks, were classified into 5 groups: control (C), aloe vera slice alone (Av), plasma-treated aloe vera slice at 5-mm distance (PTAv-5), plasma-treated aloe vera slice at 10-mm distance (PTAv-10), and plasma-treated aloe vera slice at 20-mm distance (PAV-20). Wounds were observed for 14 days. Histological evaluation using general staining for re-epithelialization was also conducted. The "dropped-water method" was able to identify surfatic RONS. Additionally, this investigation revealed that sizes of wound areas in groups containing an aloe vera slice, from days 2 to 14, were significantly smaller compared with the control group. During the proliferative phase, wound size in PTAv-20 was smaller than that in both PTAv-5 and PTAv-10. From days 4 to 7, wound size in PTAv-20 was slightly smaller than that in Av; however, wound size in PTAv-5 and PTAv-10 was greater than that in PTAv-20. On day 7, re-epithelialization percentages in Av and PTAv-20 were significantly higher than in C. It was concluded that plasma-treated aloe vera has the ability to influence the proliferative phase of wound healing.

Item Type:	Other
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S2-Master of Pharmacy (S2-Farmasi)
Depositing User:	Laela
Date Deposited:	18 Jun 2022 03:58
Last Modified:	18 Jun 2022 03:58
URI:	http://eprints.uad.ac.id/id/eprint/35406

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