Bukti Review Artikel-Combination of black cumin seeds with Curcuma xanthorrhiza extract as an antioxidant and immune-modulator agent in the COVID-19 pandemic era

Akrom, Akrom and Hidayati, Titiek and Umam, Nurcholid (2022) Bukti Review Artikel-Combination of black cumin seeds with Curcuma xanthorrhiza extract as an antioxidant and immune-modulator agent in the COVID-19 pandemic era. IJPHS, Universitas Ahmad Dahlan.

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Abstract

The COVID-19 pandemic demands changes in using of medicinal plants.
Empirically, the medicinal plants of Curcuma xanthorrhiza (CX) and black
cumin (BC) have been used massively in the era of the COVID-19
pandemic. Curcuma xanthorrhiza and black cumin (CXBC) preparations
have been developed with the main ingredients of BC oil and CX extract.

The purpose of the study was to determine the antioxidant and immune-
modulatory activities of CXBC preparations active substances (polyphenols,

flavonoids, thymoquinone). We conducted experimental laboratory research.
The immunomodulatory activity test was carried out on human large lung
cancer cell line (HTB-183 cells) by observing the expression of tumor
necrosis factor alfa (TNF-α) and interleukine 10 (IL-10). The results showed
that the CXBC preparation contained 4% thymoquinone, 25.87 mg/ml
polyphenols, and 41.86 mg/dl flavonoids. CXBC preparations contain
vitamins (A, C, and E) and minerals (potassium, calcium). The antioxidant
activity of the CXBC preparation was included in the strong category with
IC50=54.87 ppm. CXBC preparations increased TNF-a expression and
decreased IL-10 expression in HTB-183 cells. Based on the study results, it
can be concluded that the CXBC preparation contains 4% thymoquinone,
25.87 mg/ml polyphenol, 41.86 mg/dl flavonoid, and a high level of vitamin
and minerals. CXBC preparations have potent antioxidant activity, increase
TNF-α and decrease IL-10 expression.

Item Type:	Other
Subjects:	Z Bibliography. Library Science. Information Resources > Z665 Library Science. Information Science
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi)
Depositing User:	Akrom Akrom
Date Deposited:	27 Jun 2022 01:59
Last Modified:	27 Jun 2022 01:59
URI:	http://eprints.uad.ac.id/id/eprint/35552

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