Hasil similarity cek_Thymoquinone Increased Expression of CD4CD25Treg in Sprague-Dawley Rats Induced Dimethylbenzanthracene

Akrom, Akrom and Hidayati, Titiek and Indrayanti, Indrayanti and sun, sunny (2021) Hasil similarity cek_Thymoquinone Increased Expression of CD4CD25Treg in Sprague-Dawley Rats Induced Dimethylbenzanthracene. Open Access Macedonian Journal of Medical Sciences., Ukraine.

Text HASIL CEK_60990196_oamjms-t4-87-3-maret-2021.pdf Download (1MB)

Abstract

BACKGROUND: The carcinogen dimethylbenzanthracene (DMBA) is immunotoxic. Thymoquinone, meanwhile, is
known to have antioxidant and anti-inflammatory effects.
AIM: This study aims to determine the effect of thymoquinone and tamoxifen on the CD4CD25Treg count in Sprague�Dawley (SD) rats induced by DMBA.
METHODS: The 50 SD rats were divided into five groups. Group I (normal control) was given standard drinking
and food. Group II was given thymoquinone, Group III was given tamoxifen, Group IV was given DMBA, and Group
V was given solvent control. Thymoquinone, tamoxifen, and solvent control administration started 2 weeks before
DMBA administration and continued during DMBA induction. In the 3rd week, except for the normal group, all groups
were created to be induced with 10 × 20 mg/kg body weight of DMBA for 5 weeks. In the 21st week, surgery and data
collection were performed. The hematology profile and CD4CD25Treg number were carried out employing a flow
cytometer. The difference in the average number of CD4CD25Treg and blood cells between groups was analyzed
with one-way analysis of variance
RESULTS: The results revealed that DMBA induction reduced the number of erythrocytes, HB levels, platelet counts,
and leukocyte counts (p < 0.05). The administration of thymoquinone and tamoxifen reduced the hematopoiesis
effect of DMBA. The thymoquinone and tamoxifen group had a higher number of CD4CD25Treg and leukocytes than
the DMBA group (p < 0.05).
CONCLUSION: There was no difference in the average CD4CD25Treg, leukocyte count, lymphocyte count, and
monocyte count between the thymoquinone and the tamoxifen groups (p > 0.05).

Item Type:	Other
Subjects:	Z Bibliography. Library Science. Information Resources > Z665 Library Science. Information Science
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi)
Depositing User:	Akrom Akrom
Date Deposited:	27 Jun 2022 03:37
Last Modified:	27 Jun 2022 03:37
URI:	http://eprints.uad.ac.id/id/eprint/35580

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