Free fatty acids regulating action of Capparis decidua fruit on dyslipidemia in rats

Saha, Avijit and Ghosh, Sangeeta and Alok K. Hazra, Alok K. and Ghosh, Sandip and Kumar Sur, Tapas (2022) Free fatty acids regulating action of Capparis decidua fruit on dyslipidemia in rats. Pharmaciana, 12 (2). pp. 188-195.

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Abstract

Capparis decidua belongs to family Capparidaceae in wastelands of India. The study aim was to
determine the role of C. decidua fruits on the free fatty acids (FFA) profile in fat-rich diet (FRD)
dyslipidemic rats. The methanolic extract of edible fruit of C. decidua (CD) was given orally to obese
dyslipidemic rats at the dose of 125 mg/kg and 250 mg/kg for consecutive 28 days. CD treatment in
FRD rats significantly restricts the body weight gains. Blood lipid profile was altered dose dependently
and significantly after 4-week treatment with CD to FRD. rats. It significantly (p<0.05) enhanced serum
FFA especially, -linolinate, -linolinate, arachidonate, ecosapentaenoate, docosapentaenoate and
docosahexaenoate. Moreover, 3-PUFA content was also enhanced (50.3% and 78.8%) in the serum of
CD treated animals, whereas MUFA was lowered (31.1% and 40%). Therefore, Capparis decidua fruit
has a promising role on dyslipidemia and obesity and has the capabilities to regulate beneficial free fatty
acids.

Item Type:	Artikel Umum
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi)
Depositing User:	jurnal pharmaciana
Date Deposited:	21 Jul 2022 06:02
Last Modified:	21 Jul 2022 06:02
URI:	http://eprints.uad.ac.id/id/eprint/35935

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