Hasil cek similarity" Efektivitas Perlakuan Kombinatif Plasma Medis dan Ekstrak Daun Sirih untuk Mempercepat Penyembuhan Luka Fase Proliferasi pada Model Mencit Diabetik"

Wahyuningtyas, Eka Sakti and Nasruddin, Nasruddin and Esti Rahayu, Heni Setyowati and Lutfiyati, Heni and Sikumbang, Isabella Meliawati and Nurani, Laela Hayu and Rohmani, Afiana and Salsabila, Nia and Ayu Putri, Gela Setya (2019) Hasil cek similarity" Efektivitas Perlakuan Kombinatif Plasma Medis dan Ekstrak Daun Sirih untuk Mempercepat Penyembuhan Luka Fase Proliferasi pada Model Mencit Diabetik". Jurnal Ilmiah Kesehatan Keperawatan, 15 (2). ISSN P-ISSN 1858-0696 E-ISSN 2598-9855

Text HASIL CEK_Eka Sakti Wahyuningtyas, Nasruddin, Heni Setyowati Esti Rahayu, Heni Lutfiyati , Isabella Meliawati Sikumbang, Laela Hayu Nurani, Afiana Rohmani.pdf Download (2MB)

Abstract

The continued increase in the number of people with Diabetes Mellitus (DM) in
Indonesia is a serious problem. One of the big problems for people with
Diabetes Mellitus (DM) is the emergence of complications of diabetic wounds.
To date the strategy for treatment of diabetic wounds has been limited to the use
of wound dressing, cell therapy and oxygen therapy. The problem is that the
strategy is not fully successful. Thus, it is very important to look for new
strategies to improve the quality of diabetic wound healing, such as by applying
a combination of plasma medicine and local natural product, like the extraction
of Daun sirih (Piper betle) leaves. Plasma medicine is a relatively new and
multidisciplinary study involving plasma science, biomedical, pharmaceutical
and other health sciences aimed at applying plasma to therapeutic health.
Plasma is the fourth phase of matter, after the solid, liquid and gas phase. The
medical aspects of plasma are related to the ability of plasma to produce
biological molecules Reactive Oxygen and Nitrogen Species (RONS). If RONS is
controlled in the right dosage it can be efficacious for health therapy. This study
intends to examine the effects of combinative treatment of plasma medicine and
Piper betel leaf extract for proliferation phase of wound healing in diabetic
small animal model. This study used male Balb c mice with acute wounds which
were divided into 5 groups, namely groups of untreated normal mice (ND-TP),
groups of untreated diabetic mice (D-TP), groups of diabetic mice wounds with
Piper betel leaf extract (DS ), the wound group of diabetic mice with plasma
medicine (DP) and the wound group of diabetic mice with plasma medicine and
Piper betel leaf (DPS). The plasma medicine was treated on wound with
condition non-contact style (the plasma jet did not touch the wound) with a
distance of plasma jet reactor nozzle to the surface of wound about 20 mm, for 2
minutes, every day. Macroscopic observation of wounds is carried out every day
from day 0 to 7. On day 7 it was seen that the size of the wound area for D-P-S
was smaller than the other groups. The results of this study indicated that Piper
betel leaf extract can potentially be used to optimize the performance of plasma
medicine in accelerating diabetic wound healing during the proliferation phase.
Further investigation, however, is important to be conducted to study the effect
for all phases of wound healing and its mechanism histo-pathologically.

Item Type:	Artikel Umum
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S2-Master of Pharmacy (S2-Farmasi)
Depositing User:	Laela
Date Deposited:	27 Oct 2022 05:22
Last Modified:	27 Oct 2022 05:22
URI:	http://eprints.uad.ac.id/id/eprint/36975

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