Bukti Korespondensi-Combination of Black Cumin Seeds with Curcuma xanthorrhiza Extract as an antioxidant and immune-modulator agent in the Covid-19 PandemicEra

Akrom, Akrom and Hidayati, Titiek and Umam, Nurcholid and Zukhruf Saputri, Ginandjar (2022) Bukti Korespondensi-Combination of Black Cumin Seeds with Curcuma xanthorrhiza Extract as an antioxidant and immune-modulator agent in the Covid-19 PandemicEra. International Journal of Public Health Science (IJPHS), 99 (1). ISSN 2252-8806

Text CXBC-revised-1-rebbuttal letter.pdf Download (1MB)

Abstract

The COVID-19 pandemic demands changes in using of medicinal plants.
Empirically, the medicinal plants of Curcuma xanthorrhiza (CX) and black
cumin (BC) have been used massively in the era of the covid-19 pandemic.
CXBC preparations have been developed with the main ingredients of BCoil
and CX extract. The purpose of the study was to determine the antioxidant
and immune-modulatory activities of Curcuma xanthorrhiza and black
cumin (CXBC) preparations active substances (polyphenols, flavonoids,
thymoquinone). We conducted experimental laboratory research. The
immunomodulatory activity test was carried out on human large lung cancer cell
line (HTB-183 cells) by observing the expression of tumor necrosis factor alfa
(TNF-α) and interleukine 10 (IL-10). The results showed that the CXBC
preparation contained 4% thymoquinone,25.87mg/ml polyphenols, and 41.86
mg/dl flavonoids. CXBC preparations contain vitamins (A, C, and E) and
minerals (potassium, calcium). The antioxidant activity of the CXBC
preparation was included in the strong category with IC50 = 54.87 ppm.
CXBC preparations increased TNF-a expression and decreased IL-10
expression in HTB-183 cells. Based on the study results, it can be concluded
that the CXBC preparation contains 4% thymoquinone,25.87 mg/ml
polyphenol, 41.86 mg/dl flavonoid, and a high level of vitamin and minerals.
CXBC preparations have potent antioxidant activity, increase TNF-α and
decrease IL-10 expression.

Item Type:	Artikel Umum
Subjects:	Z Bibliography. Library Science. Information Resources > Z665 Library Science. Information Science
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi)
Depositing User:	Akrom Akrom
Date Deposited:	13 Feb 2023 07:10
Last Modified:	13 Feb 2023 07:10
URI:	http://eprints.uad.ac.id/id/eprint/39825

Actions (login required)

View Item