Phytochemical Investigation of Bauhinia winitii Based on Alpha‑Glucosidase Inhibitory Effect and Molecular Docking Affirmation

Dej‑adisai, Sukanya and Rais, Ichwan Ridwan and Wattanapiromsakul, Chatchai and Pitakbut, Thanet (2021) Phytochemical Investigation of Bauhinia winitii Based on Alpha‑Glucosidase Inhibitory Effect and Molecular Docking Affirmation. Pharmacognosy Magazine, 17 (76).

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Abstract

Background: Bauhinia winitii (BW) (Fabaceae) plant revealed poor
phytochemical investigation and anti‑diabetic report. As one of the
Bauhinia family which known with abundant flavonoids content, contrary,
BW was only used for the treatment of diarrhea in Thai conservative
remedy. Objectives: The aim of this study was to investigate the
phytochemical constituents and anti‑alpha glucosidase activity of BW.
Materials and Methods: Phytochemical study was based on the
alpha‑glucosidase inhibitory effect. Isolated compounds were determined
by chromatographic and spectroscopic techniques. The alpha‑glucosidase
enzymatic inhibitory test was then connected with molecular docking
affirmation. Results: The ethyl acetate and ethanol extracts from leaves
and woods exhibited the strongest activity with above 60% inhibition.
Six compounds were isolated from these extracts, naringenin (1),
luteolin (2), isoquercitrin (3), griffonilide (4), lithospermoside (5), and epi‑β
amyrin (6). The alpha‑glucosidase inhibitory test showed that flavonoids
performed potential results with naringenin as the highest IC50 on 0.41
mM. The docking ensured the flavonoids activated at the same binding
of alpha‑glucosidase enzyme active site. Conclusion: This study would
be the first report of chemical constituents from BW with its isolated
compounds was presented anti‑diabetic activity as alpha‑glucosidase
inhibitors.

Item Type:	Artikel Umum
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi)
Depositing User:	Ichwan Ridwan Rais
Date Deposited:	02 Mar 2023 09:44
Last Modified:	25 Mar 2023 03:50
URI:	http://eprints.uad.ac.id/id/eprint/40318

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