Hasil cek similarity" Chemometrics-Assisted UV-Vis Spectrophotometry for Quality Control of Pharmaceuticals: A Review"

Nurani, Laela Hayu and Edityaningrum, Citra Ariani and Irnawati, Irnawati and Putri, Anggita Rosiana and Windarsih, Anjar and Guntarti, Any and Rohman, Abdul (2023) Hasil cek similarity" Chemometrics-Assisted UV-Vis Spectrophotometry for Quality Control of Pharmaceuticals: A Review". Indones. J. Chem.

Text Chemometrics-Assisted UV-Vis Spectrophotometry for Quality Control of Pharmaceuticals_ A Review.pdf Download (7MB)

Abstract

Spectroscopic method in the UV-Vis region is considered the most molecular
spectrometric method for content determination of a single component. However, a lot of
pharmaceutical dosage forms comprise two or more components which lead to peak
overlapping. Moreover, in the chemical stability test, active pharmaceutical ingredient
(API) was also found along with the degradation products, impurities, and adulterant
compounds. UV-Vis spectroscopy is one of the methods of choice for the determination or
quantification of a single component in pharmaceutical preparations. The
pharmaceutical products typically contain two or more APIs having chromophoric agents
capable of absorbing UV-Vis beams and the absorbance values are summative from the
absorption of each UV-Vis active compound according to the additive nature of LambertBeer law. The main problem for the simultaneous determination of API along with
impurities and the degradation products in pharmaceutical preparations is the presence
of overlapping peaks of UV-Vis spectra. The chemometrics-assisted spectroscopy is one of
the analytical efforts to solve these problems. This review highlighted the application of
chemometrics in combination with UV-Vis spectroscopy for the assay of API, impurities,
adulteration issues and degradation products present in pharmaceutical dosage forms.

Item Type:	Artikel Umum
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S2-Master of Pharmacy (S2-Farmasi)
Depositing User:	Laela
Date Deposited:	28 Mar 2023 05:59
Last Modified:	28 Mar 2023 05:59
URI:	http://eprints.uad.ac.id/id/eprint/41670

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