Larvicidal activity of granulated pharmaceutical products using Indonesian holy basil leaf extract

Azis, Ikhsanudin and Lolita, Lolita Larvicidal activity of granulated pharmaceutical products using Indonesian holy basil leaf extract. [Artikel Dosen]

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Abstract

Ocimum sanctum Linn, known as holy basil, is a larvicide, which is relatively
safe compared to synthetic insecticides. This study investigates the larvicidal
activity of a granule formulation of Indonesian holy basil leaf extract against
third larval instar of Aedes aegypti. The extract of holy basil leaves was
obtained by a maceration process with 96% ethanol. The granule was
formulated with various concentrations of holy basil leaf extract, including
F1 (2000 ppm), F2 (4000 ppm), and F3 (6000 ppm). The extract contained
terpenoid, alkaloid, saponin, flavonoid, and polyphenol compounds. The
extract granules had a moisture content of 3.01%, flowability of 1.51
seconds, and dispersion time of 1.09 seconds. The mortality rates of
mosquitos treated with the different formulation groups were significantly
different from positive control with values of 25.33% (F1), 50.67% (F2), and
90.67% (F3). In conclusion, the granulated formulation of holy basil leaf
extract has a larvicidal LC50 of 4405.803 ppm and LC90 of 6080.714 ppm.
Therefore, a granulated pharmaceutical product derived from holy basil leaf
extract could be developed as a potent larvicide to control dengue fever.

Item Type:	Artikel Dosen
Subjects:	R Medicine > RS Pharmacy and materia medica
Depositing User:	apt lolita umar
Date Deposited:	18 Apr 2023 09:47
Last Modified:	18 Apr 2023 09:47
URI:	http://eprints.uad.ac.id/id/eprint/42998

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