Development of transdermal patch preparations binahong leaf extract (Anredera cordifolia (Ten.) Steenis) and antihyperglycemia test in rats

Ramadhan, Galang Pergiawan and Wahyuningsih, Iis and Widyaningsih, Wahyu (2023) Development of transdermal patch preparations binahong leaf extract (Anredera cordifolia (Ten.) Steenis) and antihyperglycemia test in rats. Pharmaciana, 13 (2). pp. 224-231. ISSN ISSN:2088-4559,e-ISSN:2477-0256

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Abstract

Binahong (Anredera cordifolia) leaves are plants that have great potential as antihyperglycemics,
and have chemical content including triterpenoids, flavonoids, and saponins. However, the development
of binahong leaves in pharmaceutical preparations is still very lacking. Objectives of this study are
knowing the transdermal patch formulation of binahong leaf extract (BLE) produces good physical
properties and the development of BLE transdermal patches with different extract concentrations may
blood glucose lower (BGL) levels in glucose-induced mice. This study uses a single-layer patch because
it has the advantage of being able to penetrate faster and is suitable for compounds that have solubility
in polar solvents. The research began with the extraction of binahong leaves, then formulated a
transdermal BLE patch using a formula that includes HPMC (polymer), glycerol (plasticizer), oleic acid
(enhancer) and tween 80 (enhancer). Diabetic rats were divided into 4 groups of 6 rats, negative control
group (glucose + placebo), positive control group (glucose + insulin), FI group (glucose+ transdermal
patch BLE 30%), and FII group (glucose + transdermal patch BLE 47%). The BGL measurements are
carried out on the 0th, 3rd, 5th, and 7th days. The physical characterization carried out includes
organoleptic, weight uniformity, thickness, pH, folding resistance, and moisture content, obtained FI
and FII results that meet the requirements set out by each test standard. The BGL from day 1 to day 7
decreased in each group, positive control (68.8±3.76), negative control (112.5±6.89), FI (81.0±4.04),
and FII (72.33±5.12). Based on the statistical results of the T-test on the physical evaluation of BLE
transdermal patch preparations of FI and FII there were significant differences in weight and thickness
uniformity, but there were no significant differences in pH, folding power, and humidity tests. The
administration of a 47% BLE in FII transdermal patch provides insignificant BGL reduction effect
compared to the 30% BLE in FI transdermal patch.

Item Type:	Artikel Umum
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi)
Depositing User:	jurnal pharmaciana
Date Deposited:	19 Aug 2023 03:49
Last Modified:	19 Aug 2023 03:49
URI:	http://eprints.uad.ac.id/id/eprint/46433

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