Effect of Papaya flower ethanolic extract (Carica Papaya) on the time kill of tetracyclin against Escherichia Coli

Anugraheni, Anugraheni and Rini, Chylen Setiyo (2023) Effect of Papaya flower ethanolic extract (Carica Papaya) on the time kill of tetracyclin against Escherichia Coli. Pharmaciana, 13 (2). pp. 246-256. ISSN ISSN:2088-4559,e-ISSN:2477-0256

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Abstract

Papaya (Carica papaya) is found throughout Indonesia. Papaya flowers contain saponin, tannin,
alkaloid, and flavonoid compounds which functions as antibacterial. Escherichia coli is a Gram-negative
rod bacteria that could be found in the human large intestine as a cause of diarrhea. The study aimed to
determine the effect of papaya flower extract and a combination of papaya flower extract with
tetracycline antibiotics using the smallest concentration capable of inhibiting 50% of bacterial growth
against Escherichia coli bacteria ATCC 25922 using the time-kill test method. This study used the
method of Minimum Inhibitory Concentration (MIC) and time-kill. The MIC of the ethanol extract of
papaya flower was 2 mg/mL. The time-kill test showed that the death phase was occurred at 4 - 24 hours.
The bacteriostatic effect of the extract was obtained at 0 hours to 24 hours, while the antibiotic and its
combination with the extracts had a bactericidal effect at 8 hours and 24 hours.

Item Type:	Artikel Umum
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi)
Depositing User:	jurnal pharmaciana
Date Deposited:	19 Aug 2023 03:49
Last Modified:	19 Aug 2023 03:49
URI:	http://eprints.uad.ac.id/id/eprint/46472

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