Nugrahani, Ilma and Utami, Dwi and Ayuningtyas, Livia and Garmana, Afrillia Nuryanti and Oktaviary, Rozana New Preparation Method Using Microwave, Kinetics, In Vitro Dissolution-Diffusion, and Anti-Inflammatory Study of Diclofenac- Proline Co–Crystal. ChemistrySelect. ISSN 23656549 (Unpublished)
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Abstract
In this study, we developed a novel and simple method to
prepare an established diclofenac-proline co-crystal (DPC) using
microwave. In addition, we also evaluate the pharmaceutical
properties of the co-crystal, including dissolution, diffusion, and
anti-inflammatory profile. The kinetics of co-crystal formation
was investigated using Fourier-transform infrared spectroscopy.
The co-crystal yield was confirmed physically by differential
scanning calorimetry and powder x-ray diffraction, while the
chemical stability of the drug during and after microwaving
was confirmed using thin layer chromatography, ultraviolet
spectrophotometry and high-performance liquid chromatography.
Experiment results demonstrated that microwave can
generate the stable and uniform quality of diclofenac-proline
co-crystal efficiently. Furthermore, the process was investigated
to follow a second order kinetic, which is different than the
neat-grinding process previously reported. Moreover, our
findings revealed that co-crystals with L-proline can significantly
improve the dissolution, diffusion, and anti-inflammation
activity of diclofenac acid.
| Item Type: | Artikel Umum |
|---|---|
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisi / Prodi: | Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi) |
| Depositing User: | Dr Dwi Utami, M.Si.,Apt |
| Date Deposited: | 23 Oct 2023 01:33 |
| Last Modified: | 23 Oct 2023 01:33 |
| URI: | http://eprints.uad.ac.id/id/eprint/51077 |
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