Hepatoprotective Effect Of Hibiscus Sabdariffa L Extract On 7,12- dimethylbenz(α) antracene (dmba) Induced Rat)

Nurkhasanah, Nurkhasanah and Rahardhian, Muhammad Ryan Radix (2015) Hepatoprotective Effect Of Hibiscus Sabdariffa L Extract On 7,12- dimethylbenz(α) antracene (dmba) Induced Rat). International Journal of Biological & Medical Reseach, 6 (1). pp. 4705-4708. ISSN 0976:6685

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Abstract

Rosella (H.sabdariffa L) extract has been reported to have antioxidants effect. Antioxidant has
important role on detoxification and metabolism of xenobiotic. The objective of this study was
to to investigate the effect of ethanolic extract from Roselle Calyx on activity of Serum Glutamic
Pyruvic Transaminase (SGPT), Serum Glutamic Oxaloacetic Transaminase (SGOT), Alkaline
phospatase (ALP) and liver histopathologic profile of Sprague Dawley (SD) rats induced by
DMBA.The study found that activity of SGPT, SGOT and ALP were increase after DMBA
treatment. The rosella extract showed to reduce the activity of SGPT, SGOT and ALP indicating
hepatoprotective effect. The histopathology of liver rat induced by DMBA after 33 days
treatment of rosella extract showed repairing effect on dependent manner.
Keywords:
Hibiscus sabdariffa
hepatoprotective
SGPT
SGOT
ALP

Item Type:	Artikel Umum
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S2-Master of Pharmacy (S2-Farmasi)
Depositing User:	Dr Nurkhasanah Mahfudh
Date Deposited:	08 Sep 2017 03:50
Last Modified:	08 Sep 2017 03:50
URI:	http://eprints.uad.ac.id/id/eprint/7267

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