PENGARUH PEMBERIAN SEDIAAN NANOPARTIKEL KITOSAN EKSTRAK ETANOL ROSELA (Hibiscus sabdariffa L.) PADA TIKUS HIPERKOLESTEROL TERHADAP PROFIL LIPID.

Safitri, Meta and Nurkhasanah, Nurkhasanah and Hayu Nurani, Laela (2014) PENGARUH PEMBERIAN SEDIAAN NANOPARTIKEL KITOSAN EKSTRAK ETANOL ROSELA (Hibiscus sabdariffa L.) PADA TIKUS HIPERKOLESTEROL TERHADAP PROFIL LIPID. KARTIKA JURNAL ILMIAH FARMASI, 2 (1). pp. 28-34. ISSN 2354-6565

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Abstract

The purpose of this study was to determine the effect of chitosan nanoparticles preparation
Ethanol Extract Roselle (SNKEER) on the lipid profile of Sprague Dawley rat strain-induced
hypercholesterolemia. Making SNKEER done based on the results of the optimization with a
ratio of 2: 1: 1/10 (ethanol extract of roselle (EER): chitosan: TPP), further in vivo tests using
female white rat strain Sprague Dawley (SD) age of 6-8 weeks a number of 25 were divided
into 5 groups: group I (K1) is the control group were fed a standard; group II (K2) induced
hypercholesterolemia; and group III (3), IV (4), and V (5) induced hypercholesterolemia and
SNKEER each at a dose of 25, 50, and 100 mg / kg, for 30 days. On day 31, all test animals
orbital venous blood drawn through the eye to be measured lipid profile (total cholesterol, LDL
cholesterol, HDL, triglycerides). Analysis for this study is followed by Tukey follow-up test
5%. The results of the study the average measurements of lipid profile is the measurement of
cholesterol K1, K2, K3, K4, K5 were 106.76; 233.45; 197.63; 158.61; 133.94 mg / dl
respectively, Triglycerides: 73.33; 125.51; 107.97; 90.43; 80.87 mg / dl, HDL: 44.41; 14.45;
18.19; 23.68; 30,90mg / dl, LDL: 51.58; 72.24; 63.16; 54.61; 51.84 mg / dl. The results of the
data analysis showed that the group SNKEER doses (25, 50, 100 mg / kg body weight) can significantly have effect on the increasing of the lipid profile, especially in the lower levels of
total cholesterol, triglycerides, and LDL levels and HDL levels significantly when compared to
hypercholesterolemia (K2). The treatment group that produces the best improvements in lipid
profiles was SNKEER group with dose of 100 mg / kg when compared to all treatment groups
(P <0.05).
Key words : Roselle, Nanoparticles, hypercholesterolemia, lipid profile

Item Type: Artikel Umum
Subjects: R Medicine > RS Pharmacy and materia medica
Divisi / Prodi: Faculty of Pharmacy (Fakultas Farmasi) > S2-Master of Pharmacy (S2-Farmasi)
Depositing User: Dr Nurkhasanah Mahfudh
Date Deposited: 12 Oct 2017 05:10
Last Modified: 12 Oct 2017 05:10
URI: http://eprints.uad.ac.id/id/eprint/7649

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