Gastroprotective activity of Banana peel (Musa paradisiaca var. sapientum) methanol extract purified on aspirin-induced gastric ulceration in Rats

Pusmarani, Jastria and Putri, Risky Juliansyah and Dewi, Citra and Fitriani, Difa and Purwono, Setyo and Ikawati, Zullies (2024) Gastroprotective activity of Banana peel (Musa paradisiaca var. sapientum) methanol extract purified on aspirin-induced gastric ulceration in Rats. Pharmaciana, 14 (3). ISSN ISSN:2088-4559,e-ISSN:2477-0256

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Abstract

Banana (Musa paradiasiaca var. sapientum) is the world's most popular fruit-bearing crop, with
rising consumption and waste. This study aimed to measure the metabolite compound and evaluate the
gastroprotective properties of a banana peel-purified methanol extract. Animals test used in this study
were divided into six groups: Group One received NaCMC 0.5%, Group Two received sucralfate, Group
Three received aspirin 1000 mg/kg body weight, and groups four, five, and six received PBP at doses of
200 mg/kg body weight, 400 mg/kg body weight, and 600 mg/kg body weight, respectively, for seven
days. Except for group 1, all groups were induced with aspirin at 1000 mg/kg body weight on the eighth
day. The result of this study exhibited banana peel containing total phenolic, flavonoid, and tannin
compounds with concentrations of 33.45 mg GAE/g, 19.92 mg QE/g, and 0.16 %, respectively. The
results showed that pure extract of Musa paradiasiaca var. sapientum fruit peel can reduce the incidence
of gastric ulcers by decreasing the ulcer index (p<0.05). The results suggested that Musa paradisiaca
var. sapientum peel has a gastroprotective effect against aspirin-induced gastric ulceration.

Item Type: Artikel Umum
Subjects: R Medicine > RS Pharmacy and materia medica
Divisi / Prodi: Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi)
Depositing User: jurnal pharmaciana
Date Deposited: 19 Apr 2025 07:48
Last Modified: 19 Apr 2025 07:48
URI: http://eprints.uad.ac.id/id/eprint/83051

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