Optimization of self-nanoemulsifying drug delivery system of rifampicin for nebulization using cinnamon oil as oil phase

Ricardo, I Komang Aan Adi and Arimurni, Dewa Ayu (2024) Optimization of self-nanoemulsifying drug delivery system of rifampicin for nebulization using cinnamon oil as oil phase. Pharmaciana, 14 (3). ISSN ISSN:2088-4559,e-ISSN:2477-0256

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Abstract

Lung delivery can overcome the problems related to the effectiveness of tuberculosis treatment by
increasing the drug concentration at the target site. Rifampicin as the first-line antibiotic for tuberculosis
has low water solubility and is unstable in gastric which hinders its effectiveness. Self-nanoemulsifying
drug delivery system (SNEDDS) is a strategy known to improve the solubility and stability of such
drugs. This study aimed to obtain the optimum formula of rifampicin SNEDDS intended for lung
nebulization using essential oil as an oil phase. Several essential oils are known to have effective
antibacterial on Mycobacterium tuberculosis. However, a high capability to solubilize the drug is
required for SNEDDS formulation. Cinnamon oil, tween 80, and transcutol P were chosen as SNEDDS
components for optimization using a D-optimal mixture based on the physicochemical characteristics.
The optimum formula comprised 12.65% cinnamon oil, 75.00% tween 80, and 12.35% transcutol P
which dispersed easily to form a highly transparent emulsion in normal saline under 1 minute. Upon
dilution with saline, the optimal SNEDDS can produce a homogenous nanometer droplet (169.2±19.771
nm, PDI of 0.258±0.070) with acceptable pH for lung administration. It also has a viscosity similar to
water (0.94±0.01 cP) which allows it to be nebulized easily (aerosol output rate of 0.14±0.02 g/min).
Although the diluted SNEDDS has a zeta potential of -2.533±0.268 mV, it was stable for up to 4 hours
during the nebulization. These results indicate the potential of cinnamon oil-based rifampicin SNEDDS
to be an alternative in the pulmonary delivery of rifampicin via nebulization.

Item Type:	Artikel Umum
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi)
Depositing User:	jurnal pharmaciana
Date Deposited:	21 Apr 2025 01:24
Last Modified:	21 Apr 2025 01:24
URI:	http://eprints.uad.ac.id/id/eprint/83055

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