Impact of Black Garlic extract on cardio-renal protection in hypertensive animal models

Hasimun, Patonah and Putra, Hendra Mahakam and Choerunnisa, Fitriani (2025) Impact of Black Garlic extract on cardio-renal protection in hypertensive animal models. Pharmaciana, 15 (1). ISSN ISSN:2088-4559,e-ISSN:2477-0256

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Abstract

A strong link exists between arterial stiffening and cardiovascular conditions, particularly
hypertension. Hypertension, a significant contributor to mortality rates, particularly affects elderly
populations. The processed form of Allium sativum, known as black garlic, is renowned for its medicinal
properties, including its ability to lower blood pressure. This study examined the blood pressurelowering
effects of black garlic extract, employing male Wistar rats aged two to three months.The
experiment involved six distinct rat groups, each comprising of four animals. The two groups served as
controls, whereas the remaining four underwent different treatments. Captopril was administered to one
group at a dose of 2.5 mg/kg, whilst the remaining three groups were given black garlic extract as BG50,
BG100, and BG200. All groups, with the exception of the control normal, underwent a 28-day induction
protocol that included 25% fructose in drinking water, cholesterol (200 mg/kg), and propylthiouracil
(12.5 mg/kg). The test substances were administered starting on day 14 concurrently with the induction
phase. The evaluated parameters included blood pressure, arterial stiffness, nitric oxide (NO) levels, and
renal histopathology. Black garlic extract significantly lowered blood pressure, enhanced arterial
elasticity, and increased NO levels (p < 0.05) compared with the controls. Renal histopathological
analysis revealed protective effects, suggesting prevention of kidney damage. These findings suggest
that black garlic may have cardiorenal protective effects and could be useful for managing hypertension
and arterial stiffness.

Item Type:	Artikel Umum
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi)
Depositing User:	jurnal pharmaciana
Date Deposited:	21 Apr 2025 01:13
Last Modified:	21 Apr 2025 01:13
URI:	http://eprints.uad.ac.id/id/eprint/83092

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