The efficacy of black cumin seed (Nigella sativa) oil and hypoglycemic drug combination to reduce HbA1c level in patients with metabolic syndrome risk

Rachman, P N R and Akrom, Akrom and Darmawan, E (2017) The efficacy of black cumin seed (Nigella sativa) oil and hypoglycemic drug combination to reduce HbA1c level in patients with metabolic syndrome risk. IOP Conference Series: Materials Science and Engineering, 259. 012018. ISSN 1757-8981

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Abstract

Abstract. Metabolic syndrome is a conditions caused by metabolic abnormalities include
central obesity, atherogenic dyslipidemia, hypertension, and insulin resistance. HbA1c
examination is required to study the long-term glycemic status and to prevent diabetic
complications of metabolic syndrome. The purpose of this study is to determine the efficacy of
black cumin seed (Nigella sativa) oil and hypoglycemic drug combination to reduce HbA1c
level in patients with metabolic syndrome risk. This research performed using an experimental
randomized single - blind controlled trial design. A total of 99 outpatients at the Jetis I Public
Health Center, Yogyakarta, Indonesia with metabolic syndrome risk were divided into three
groups: The control group received placebo and two treatment groups received black seed oil
orally at dose of 1.5 mL/day and 3 mL/day, respectively, for 20 days. The clinical conditions
such as blood pressure, pulse rate, BMI, blood glucose serum and HbA1c levels were
examined on day 0 and 21. The results obtained were analyzed with one-way ANOVA test.
The mean of HbA1c levels of all groups before treatment was higher than the normal values
and there was no significant difference in HbA1c value on day 0. Administration of 1.5 and 3
mL/day of black seed oil for 20 days decreased (p<0.05) HbA1c levels. It can be concluded
that administration of black cumin seed oil and hypoglycemic drug combination for 20 days in
patients at risk of metabolic syndrome may reduce to HbA1c levels.

Item Type:	Artikel Umum
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > Pharmacy Doc
Depositing User:	Akrom Akrom
Date Deposited:	22 Jan 2018 07:37
Last Modified:	22 Jan 2018 07:37
URI:	http://eprints.uad.ac.id/id/eprint/8599

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