Masnun, Affair and Bachri, Moch.Saiful and Nurani, Laela Hayu (2013) CEK SIMILARITY "ANTI CONVULSANT EFFECT OF Centella asiatica FRACTIONS AND HISTOPATOLOGY STUDY OF LIVER AND KIDNEY". Fakultas Farmasi, Universitas Ahmad Dahlan, Proseding ICCMCCR.
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Abstract
Background. Seizure is an neurologik issue that relatively much be found. Treatment with
conventional chemical remedies are more expensive beside their limited distribution. conventional
remedies have a lot of side effects. Therefore, needed to find a new alternative treatment that more
safe, effective and selective to suppress seizure as anti convulsant. Pennywort ( Centella asiatica (b)
urb ) has effect as anti convulsant. Ethanol extract of Pennywort herb also known could have sedative
effects on mice because it contains with brahminoshide and brahmoshide glycosides using their
cholinergic mechanism.
Objective. The aim of this research is to know whether ethyl acetat fraction and unsoluble ethyl
acetate fraction of pennywort herb can be used as anti convulsant.
Methods. This research conducted using mice which divided in eight groups which consisted of
7 mices per group. The classification of the group consists of negative control (suspension of CMC 5
%), ethyl acetate fraction group with dose 100mg/KgBW, 200mg/KgBW, 400mg/KgBW, unsoluble
ethyl acetate fraction group with dose 100mg/KgBW, 200mg/KgBW and 400mg/KgBW, and positive
control group (fenobarbital 100mg/KgBW). To make convulsion condition, mice induced using PTZ
dose 80Kg/BW. This test lasted for 7 days. The result was analyzed by using post hoc test and Mann
Whitney method were also used to compare each sample. The significant value was accepted if
P<0.05.
Outcome measured. The parameters of anti convulsant including time of duration. The
histopatology tested on liver and kidney.
Results. Unsoluble ethyl acetate fraction dose 400 mg/KgBB has the ability to reduce duration
time. Histopathology test showed that ethyl acetat fraction dose 100mg/KgBW and unsoluble ethyl
acetat fraction dose 400mg/KgBW significantly increase repairment of kidney damage induced by
PTZ.
Conclusion. Conclusion that not all fractions have the ability as anti convulsant.
Keywords : Anti convulsant, Centella asiatica, ethyl acetate fraction, unsoluble ethyl acetate
fraction, Phentylenetetrazole (PTZ).
| Item Type: | Other |
|---|---|
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisi / Prodi: | Faculty of Pharmacy (Fakultas Farmasi) > S2-Master of Pharmacy (S2-Farmasi) |
| Depositing User: | Laela |
| Date Deposited: | 07 Mar 2018 03:50 |
| Last Modified: | 08 Nov 2019 01:32 |
| URI: | http://eprints.uad.ac.id/id/eprint/8967 |
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