Cek Similarity Gel Formulation of Ethanol Extract of Mangosteen Peel (Garcinia mangostana L.) as A Medication for Burns in Wistar Rats

Sugihartini, Nining and Yeshi Wiradhika, Rinanda (2017) Cek Similarity Gel Formulation of Ethanol Extract of Mangosteen Peel (Garcinia mangostana L.) as A Medication for Burns in Wistar Rats. Fakultas Farmasi Universitas Islam Indonesia.

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Abstract

Background: Mangosteen peel (Garcinia mangostana L.) has been shown
to stimulate the regeneration of damaged body cells and have an antimicrobial
activity that can be beneficial in healing burns. Therefore, it is
necessary to make it into a gel dosage form that has the advantages of
being easily washed with water, high adhesion, cooling of the skin, and
good drug release.
Objective: To determine the effect of varying concentrations of ethanol
extract of mangosteen peel in a gel formulation on wound healing in burns
and the physical properties of the gel.
Methods: Mangosteen peel extract was obtained by maceration method
using ethanol 70%. This extract was formulated in a gel dosage form
with variations of extract concentration, namely F I (5%), F II (10%),
and F III (15%). The gels were then tested for their physical properties
(organoleptic, homogeneity, pH, spreadability, adhesiveness, and physical
stability) and their activity against burns experimentally using mice as
test animals. Burns were made by using a hot plate with an area of 2 cm
x 2 cm.
Results: The increase of extract concentration could increase spreadability
(p>0.05), adhesiveness (p>0,05), and percentage of healing activity
against burns as shown by a significant difference between FI and FIII.
On the other hand, the difference in the concentration of the extract did
not affect pH (all formulations have pH of 3.5); all formulas also remained
homogenous and stable after centrifugation.
Conclusion: The best physical properties and wound healing activity for
burns was shown by the gel with the ethanol extract of mangosteen peel
at a concentration of 15%.
Keywords:
Gel
Burns
Physical properties
Mangosteen peel extract

Item Type:	Other
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S2-Master of Pharmacy (S2-Farmasi)
Depositing User:	Nining Sugihartini
Date Deposited:	07 Mar 2018 04:49
Last Modified:	06 Aug 2019 07:10
URI:	http://eprints.uad.ac.id/id/eprint/9070

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