Peer Review Antihypercholesterol Activity of Costus Speciosus Water Extract

Susanti, Hari and Wahyuono, Subagus and Sari, Ika Puspita and Susidarti, Ratna Asmah (2018) Peer Review Antihypercholesterol Activity of Costus Speciosus Water Extract. [Artikel Dosen]

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Introduction: Hypercholesterolemia is one of the causes of cardiovascular disease. Costus
speciosus (CS) is known empirically as an antihypercholesterol remedy. Material and Method:
This study was conducted to determine the effect of water extract of CS on cholesterol blood
serum level of rat induced-propylthiouracil (PTU). The antihypercholesterol activity performed
on male Wistar rats which induced 0.01% PTU (mixed in drinking water, 14 day-induction)
was followed by the administration of CS for 14 days. The animals were randomly divided into
seven groups: Solvent control (carboxylmethylcellulose 0.5% w/v in water), positive control
(simvastatin at dose 7.2 mg/kg BW), negative control (water), CS extract 50, 100, and 200 mg/kg,
and normal control. The cholesterol levels were measured at day 0th, 14th, and 28th. Result
and Conclusion: Results showed that administration of

Item Type: Artikel Dosen
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
R Medicine > RS Pharmacy and materia medica
Divisi / Prodi: Faculty of Pharmacy (Fakultas Farmasi) > Program of Professional Pharmacist
Depositing User: Mrs Hari Susanti
Date Deposited: 20 May 2022 03:01
Last Modified: 20 May 2022 03:01

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