Hasil cek similarity" Reducing ulcerogenic effect of self-nano emulsifying drud delivery system of piroxicam"

Wahyuningsih, Iis and Widyaningsih, Wahyu and Wulandari, Silviana (2018) Hasil cek similarity" Reducing ulcerogenic effect of self-nano emulsifying drud delivery system of piroxicam". Pharmacaiana, 8 (2). ISSN ISSN: 2088 4559; e-ISSN: 2477 0256

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Piroxicam is antiinflammatory non-steroidal (AINS) drug group that has anti-inflammatory,
analgesic and antipyretic effects. Like most other AINS drugs, piroxicam has low solubility and has
gastrointestinal (ulcerogenic) side effects on long-term use. The nano-emulsifying drug delivery
system (SNEDDS) is one of the technologies that can be used to overcome it. This study aims to
determine the effect of ulcerogenic SNEDDS piroxicam compared with piroxicam formulas instead
of SNEDDS. This study used white rats male strain Sprague Dawley (SD) age 2-3 months and
weight 100-200 g of 40 rats. Rats divided into 5 groups. Group I was a normal control group,
which were given only water. Group II was a vehicle control group which treated with a 1%
polyvinylpyrrolidone (PVP) solution, group III was a carrier control group which treated with
SNEDDS base (a mixture of tween 80, virgin coconut oil (VCO) and polyethylene glycol (PEG)
400), group IV was a group of piroxicam which reated with piroxicam 1.08 mg/Kg suspended 1%
PVP, group V was treated with SNEDDS piroxicam. Treatment was done for 28 days. After
treatment, the gastric of rats were taken to be observed for ulcerogenic effects. Observations were
made macroscopically by looking at ulcer scores followed by histopathological observations of
tissue. The ulcer score data from each group were analyzed using one-way ANOVA and LSD test.
The results showed that the normal control group, 1% PVP suspension and SNEDDS base groups
had an ulcer index of 0.0, 0.0 and 0.0 respectively, while the piroxicam suspension and the
SNEDDS groups had an ulcer index of 0.88 and 0.0. These results were confirmed by
histopathologic results of SNEDDS piroxicam in order to decrease the effect of piroxicam
ulcerogenic. It can be concluded that SNEDDS piroxicam can decrease the ulcerogenic effect.

Item Type: Artikel Umum
Subjects: R Medicine > RS Pharmacy and materia medica
Divisi / Prodi: Faculty of Pharmacy (Fakultas Farmasi) > Program of Professional Pharmacist
Depositing User: Iis Wahyuningsih
Date Deposited: 12 Nov 2022 02:26
Last Modified: 12 Nov 2022 02:26
URI: http://eprints.uad.ac.id/id/eprint/37502

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