Review Potensi Bioproses Squalene dari Mikroalga Thraustochytrid untuk Nutrasetikal di Era New Normal Diisolasi dari Hutan Bakau Indonesia

Suhendra, Suhendra and Pantoiyo, Tresya and Fazlia, Sarah and Sulistiawati, Endah and Evitasari, Rachma Tia (2021) Review Potensi Bioproses Squalene dari Mikroalga Thraustochytrid untuk Nutrasetikal di Era New Normal Diisolasi dari Hutan Bakau Indonesia. [Artikel Dosen]

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The covid-19 pandemic has been increasing people's awareness of good habits to maintain their health. Accordingly, the choice shifted more to consume nutraceutical and functional food to provide a beneficial impact. One of the essential and attractive nutraceuticals is squalene (C30H50) which has a long history the biosynthesis of cholesterol, vitamins and steroid hormones in human. A common raw material to produce squalene comes from the liver oil of a deep-sea shark. However, the strategy to use liver sharks in squalene production encountered environmental and political barriers due to strict nature protection regulations. The renewed scientific interest has found microalgae from the thraustochytrids family as a promising future source of squalene. Thraustochytrids is a group of osmo-heterotrophic marine microalgae, which can be found commonly in mangrove area.. As the country with the largest mangrove forest globally, Indonesia has the highest biodiversity potentials of Thraustochytrids. Unfortunately, the study on the potential of Thraustochytrids microalgae from Indonesian mangrove forests for squalene production has received less attention from researchers. Therefore, this paper presents Thraustochytrids' potential from Indonesian mangrove forests as a sustainable source of squalene production that can replace raw material from shark liver oil. This paper summarizes all selected strains used in the previous study and their operating parameters. Based on our review study Aurantiochytrium sp. 18W-13a–1 is the most productive Thraustochytrids which produced 0.32 g/ in the nutrients of 2.0% glucose, 1.0% tryptone, 0.5 g/l yeast, and 50% artificial seawater (ASW). Compared to squalene from other sources (yeast, bacteria, and plants), Thraustochytrid can yield more squalene. Bioprocess engineering aspects and the general uses of squalene are also presented, including the notable developments in the adjuvant vaccine of Covid-19, anti-aging substance, and anti-cancer applications.

Item Type: Artikel Dosen
Keyword: Mangrove; Microalgae;Nutraceuticals;Squalene;Thraustochytrids
Subjects: R Medicine > R Medicine (General)
S Agriculture > SF Animal culture
S Agriculture > SH Aquaculture. Fisheries. Angling
T Technology > TP Chemical technology
Divisi / Prodi: Faculty of Industrial Technology (Fakultas Teknologi Industri) > S1-Chemical Engineering (S1-Teknik Kimia)
Depositing User: Dr.-Ing. Suhendra Suhendra
Date Deposited: 30 Oct 2023 04:30
Last Modified: 30 Oct 2023 04:30

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