Anugraheni, Anugraheni and Rini, Chylen Setiyo (2023) Effect of Papaya flower ethanolic extract (Carica Papaya) on the time kill of tetracyclin against Escherichia Coli. Pharmaciana, 13 (2). pp. 246-256. ISSN ISSN:2088-4559,e-ISSN:2477-0256

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Abstract

Papaya (Carica papaya) is found throughout Indonesia. Papaya flowers contain saponin, tannin,
alkaloid, and flavonoid compounds which functions as antibacterial. Escherichia coli is a Gram-negative
rod bacteria that could be found in the human large intestine as a cause of diarrhea. The study aimed to
determine the effect of papaya flower extract and a combination of papaya flower extract with
tetracycline antibiotics using the smallest concentration capable of inhibiting 50% of bacterial growth
against Escherichia coli bacteria ATCC 25922 using the time-kill test method. This study used the
method of Minimum Inhibitory Concentration (MIC) and time-kill. The MIC of the ethanol extract of
papaya flower was 2 mg/mL. The time-kill test showed that the death phase was occurred at 4 - 24 hours.
The bacteriostatic effect of the extract was obtained at 0 hours to 24 hours, while the antibiotic and its
combination with the extracts had a bactericidal effect at 8 hours and 24 hours.

Item Type:	Artikel Umum
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi)
Depositing User:	jurnal pharmaciana
Date Deposited:	19 Aug 2023 03:49
Last Modified:	19 Aug 2023 03:49
URI:	http://eprints.uad.ac.id/id/eprint/46472
Dosen Pembimbing:	UNSPECIFIED | [error in script]

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